Postoperative delirium after cardiac surgery
Conditions
Interventions
Remimazolam group:Remimazolam
Propofol group:Propofol
Sponsors
the First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) aged 60 years or greater, (2) American Society of Anesthesiologists (ASA) physical status I–IV, (3) elective cardiac surgery with cardiopulmonary bypass, including coronary artery bypass grafting and/or valve surgery, and (4) planned ICU admission after surgery.
Exclusion criteria
Exclusion criteria: (1) allergy to medications used in this study, (2) procedures involving aortic arch, (3) use of deep hypothermic circulatory arrest or low flow; (4) preoperative left ventricular ejection fraction <30%, (5) severe hepatic or renal dysfunction (Child-Pugh class C or renal replacement therapy), (6) severe chronic respiratory disease, (7) history of mental diseases or taking antipsychotic medications, (8) preoperative Mini-Mental State Examination score =23, and (9) declined to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative time with EEG suppression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative delirium;Duration of hypotension; | — |
Countries
China
Contacts
Public ContactPeng Ke
The First Affiliated Hospital of Soochow University
Outcome results
None listed