Comparison of muscle-relaxation effects between domestic and imported rocuronium in patients undergoing laparoscopic surgery under general anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200056319

Enrollment

Unknown

Registered

2022-02-03

Start date

2022-04-01

Completion date

Unknown

Last updated

2024-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing elective laparoscopic abdominal surgery under general anesthesia

Interventions

Domestic rocuronium group:Application of domestic rocuronium in induction and maintenance of anesthesia

Imported rocuronium group:Application of imported rocuronium in induction and maintenance of anesthesia

Eligibility

Sex/Gender

All

Age

19 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 19-65 years old; 2. Weighed 40-80kg; 3. American Society of Anesthesiologists (ASA) gradeI-II, operation time >1h; 4. Preoperative Mallampatti airway assessment was graded I or II in all patients; 5. Liver and kidney function are normal; 6. No history of neuromuscular system diseases; 7. No recent use of drugs that interfere with neuromuscular transmission function or may interfere with the effects of muscle relaxants; 8. No electrolyte abnormality and acid-base balance disorders; 9. Patients scheduled for elective laparoscopic abdominal surgery under general anesthesia with endotracheal intubation and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Severe heart, lung, liver and renal dysfunction; 2. Pregnant and lactating women; 3. Patients with valvular heart disease; 4.Ppatients with neuromuscular system diseases, who used drugs that interfere with neuromuscular transmission function or affect the effect of muscle relaxants; 5. Patients with severe respiratory diseases; 6. Other anesthesia and surgical contraindications; 7. Allergic to bromide.

Design outcomes

Primary

Measure	Time frame
The muscle relaxation effect (onset time, 10% recovery time, recovery index);	—

Secondary

Measure	Time frame
The grade of endotracheal intubation conditions;Intraoperative muscle relaxation degree;Intraoperative dosage of rocuronium and average infusion rate;The BP, HR, SpO2, BIS values and PetCO2 were recorded at the basal value after patients admission, immediately after intubation, and when T1% was restored to 10%, 25%, and 75%;	—

Countries

China

Contacts

Public ContactYu Jianbo

Tianjin Nankai Hospital

yujianbo11@126.com+86 18698087176

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026