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Optimized fluid resuscitation strategy for septic shock guided by microcirculation

Optimized fluid resuscitation strategy for septic shock guided by microcirculation

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200056310
Enrollment
Unknown
Registered
2022-02-03
Start date
2017-03-01
Completion date
Unknown
Last updated
2024-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis, septic shock

Interventions

Two groups:All patients retained blood, sputum and other cultures before administration of antibiotics, and underwent continuous ECG monitoring, continuous oxygen saturation and perfusion index monito

Sponsors

The Affiliated Hospital of Hangzhou Normal University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
35 Years to 93 Years

Inclusion criteria

Inclusion criteria: According to the sepsis diagnostic criteria: clinical infection or suspicion of infection, and SOFA score >= 2. Septic shock: preexisting sepsis with circulatory swings after adequate volume resuscitation, vasoactive medications still required to maintain MAP >= 65 mmHg, and blood lactate levels > 2 mmol / L.

Exclusion criteria

Exclusion criteria: 1. Age < 18 years; 2. Those with untreated tumors; 3. Raynaud syndrome; 4. Severe peripheral vasculopathy; 5. Those with contraindications to central venous and femoral catheterization; 6. Advanced patients who cannot be treated with fluid resuscitation; 7. Pregnant or gestational patients; 8. Those with poor adherence to treatment.

Design outcomes

Primary

MeasureTime frame
Heart rate;Mean arterial pressure;Central venous pressure;Central venous blood oxygen saturation;Lactate;Liquid negative equilibrium time;ICU length of stay;

Countries

China

Contacts

Public ContactLin Leqing

The Affiliated Hospital of Hangzhou Normal University

happylin67@126.com+86 13305710671

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026