Obstructive Jaundice
Conditions
Interventions
Treatment group:Cefuroxime prophylaxis
Control group:No antibiotic prophylaxis
Sponsors
Gastroenterology Department of Drum Tower Hospital Affiliated to Medical School of Nanjing University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Biliary tract obstruction confirmed by CT scan and/or MRCP; 2. TBil > 21 umol/L; 3. Patients who are unable to or failed from ERCP drainage; 4. Refuse percutaneous transhepatic bile duct drainage (PTCD); 5. Aged 18 to 85 years; 6. Patients who agree to take this trial and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with coagulation disorders and/or cardiopulmonary insufficiency and unable to take endoscopic procedures; 2. Patients who are allergic to cephalosporin; 3. Patients with acute cholangitis, bacteremia, sepsis, and other signs of infection; 4. Pregnancy or breastfeeding; 5. Patients who do not agree to participate in the trial or refuse to sign the informed consent; 6. Patients who may not cooperate judged by the researchers; 7. Patients who are not able to take EUS-BD, judged by endoscopists in the research team.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infection-related complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Antibiotics-related complications;Endoscopic procedures;Causes of biliary tract obstruction; | — |
Countries
China
Contacts
Public ContactWang Lei
Drum Tower Hospital Affiliated to Medical School of Nanjing University
Outcome results
None listed