coronary artery disease
Conditions
Interventions
Group R:giving remimazolam 0.2-0.3mg/kg in induction
Group P:giving propofol 1-2mg/kg in induction
Group E:giving etomidate 0.1-0.2mg/kg in induction
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.ASA physical status I-IV; 2.BMI 18-20 kg/m^2; 3.Aged above 18 years; 4.Prepare to have coronary artery bypass grafting under general anesthesia; 5.Selective operation.
Exclusion criteria
Exclusion criteria: 1. Female in pregnancy or lactation and anyone prepare to give birth; 2. Having severe organ dysfunction in respiratory or circulation system or having abnormality in CBC and CMP; 3. Having severe mental illness or disease in nervous system; 4. Having benzodiazepines or opioids everyday in a month or once for two days; 5. Allergic or having contradiction using benzodiazepines, opioids, propofol, flumazenil, naloxone and their ingredients; 6. Ruled as patient with difficult airway: mallmapati score above III.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiac output; | — |
Secondary
| Measure | Time frame |
|---|---|
| cardiac index;stroke volume;system vascular resistance index;blood pressure;heart rate;the amount of vasoactive drug; | — |
Countries
China
Contacts
Public ContactMa Jun
Beijing Anzhen Hosptial, Capital Medical University
Outcome results
None listed