patients with difficult weaning in ICU
Conditions
Interventions
experimental group:external diaphragm pacing
control group:sham-EDP
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18years; 2. Patients receiving mechanical ventilation for the first time; 3. Mechanical ventilation patients who failed to wean repeatedly for 2 weeks; 4. The patient's basic condition is stable (vital signs are stable, infection is effectively controlled, nervous system function is stable, etc.); 5. Informed consent signed by family members;
Exclusion criteria
Exclusion criteria: 1. Patients whose condition has not been stable or continues to deteriorate (such as acute cardiovascular events, progressive aggravation of neurological signs, new lesions or bleeding tendency, etc.); 2. Patients with EDP contraindication (such as malignant tumor patients, pacemakers, local skin lesions of irritation sites, electric stimulation of allergy, active pulmonary tuberculosis and other infectious diseases, pneumothorax patients, etc.) 3. The vital signs fluctuated greatly during EDP treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time of successful weaning;28 day weaning rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| diaphragm thickening fraction;Oxygen partial pressure of arterial blood;Partial pressure of carbon dioxide in arterial blood;fraction of inspired oxygen;Oxygenation index; | — |
Countries
China
Contacts
Public ContactSiwei Liu
West China Hospital of Sichuan University
Outcome results
None listed