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The crosstalk between airway epithelial cells and immune cells in different phenotypes of asthma

The crosstalk between airway epithelial cells and immune cells in different phenotypes of asthma

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200056270
Enrollment
Unknown
Registered
2022-02-03
Start date
2022-03-01
Completion date
Unknown
Last updated
2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Interventions

Case series:None

Sponsors

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. The inclusion criteria for patients with asthma: (1) Informed consent is signed by study participants; (2) All asthmatic patients had a history of recurrent episodes of wheezing; (3) Pulmonary function provocation test was positive; (4) No use or intermittent use of salbutamol aerosol (less than twice a week) and no use of inhaled or oral glucocorticoids; 2. The inclusion criteria of control subjects: (1) Informed consent is signed by study participants; (2) No abnormality was found in bilateral bronchus due to pulmonary nodules and other reasons; (3) There was no history of chest tightness or wheezing, and the pulmonary function provocation test was negative.

Exclusion criteria

Exclusion criteria: 1. Subjects with a smoking history; 2. Patients with other diseases (such as COPD, bronchiectasis, respiratory tract infection), especially those with immune dysfunction.

Design outcomes

Primary

MeasureTime frame
Pulmonary function + provocation test;FeNO;Blood routine examination;IgE;Tracheobronchoscopy;Skin prick tests;ACT scores;ACQ5 scores;Medical history;

Secondary

MeasureTime frame
CT Scan of the Lungs;

Countries

China

Contacts

Public ContactGuohua Zhen

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

ghzhen@tjh.tjmu.edu.cn+86 13517277794

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026