Acute onset of chronic obstructive pulmonary disease
Conditions
Interventions
Control group:During the noninvasive interval, central oxygen driven atomization is used to inhale the atomized drug solution
Intervention group one:In the process of patients using the non-invasive ventilator, the atomizing tank that can be connected with the ventilator pipe is connected in series between the mask and the b
Intervention group two:In the process of using the non-invasive ventilator for patients, the atomizing tank and the ventilator are connected in series. The bottom of the atomizing tank is connected wi
Sponsors
The Third Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. All cases met the diagnostic criteria of AECOPD patients in the Guidelines for the Diagnosis and Treatment of Chronic obstructive Pulmonary Disease (COPD) 2021 Revision, that is, sudden worsening of respiratory symptoms in COPD patients beyond routine variation. The main symptoms are dyspnea, often accompanied by wheezing, chest tightness, cough, increased sputum volume, sputum color and/or viscosity change and fever, etc. 2. 18-80 years old; 3. The oxygen therapy method was the alternate use of a non-invasive ventilator and nasal catheter oxygen inhalation, and the use time of a non-invasive ventilator was 10h a day. 4. Able to communicate normally; 5. Patients who voluntarily participated in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Have a history of facial or gastric or esophageal surgery; 2. Head and face trauma, inherent nasopharyngeal abnormalities; 3. Complicated with other serious digestive, urinary, nervous and other organ diseases; 4. Other contraindications for non-invasive ventilation treatment, such as severe coma, giant lung bullosa, pneumothorax, mediastinal emphysema, shock, lung cancer, interstitial lung disease, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percutaneous pCO2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Partial pressure of carbon dioxide, partial pressure of oxygen, PH value in blood;Number of vital signs fluctuation during atomization;Clinical Pulmonary Infection Score (CPIS) score;COPD Assessment Test (CAT) score;Sputum score; | — |
Countries
China
Contacts
Public ContactYang Yan
The Third Affiliated Hospital of Soochow University
Outcome results
None listed