Gastroesophageal Reflux-induced Chronic Cough
Conditions
Interventions
Treatment:Abdominal deep breathing training
Control:None
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 80 years old (18 and 80 years old included); 2. Chronic cough lasting for >= 2 months, with or without typical upper gastrointestinal symptoms such as regurgitation, heartburn, and chest pain; 3. Multichannel intraluminal impedance-pH monitoring (MII-pH) revealed one or more of the followings: (1) Acid exposure time (AET) > 6%; (2) Syndrome association probability (SAP) >= 95%; (3) Reflux episodes >80/24 h; 4. Prior to the consideration of gastro-oesophageal reflux-induced chronic cough, other causes of chronic cough including upper airway cough syndrome, cough variant asthma, and eosinophilic bronchitis were excluded by negative investigations and therapeutic trials for these aetiologies according to a step by step algorithm.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women; 2. People who smoke or quit smoking within 2 years; 3. People who refused to sign IFC; 4. People with reading and writing disabilities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The success rate of cough symptom; | — |
Secondary
| Measure | Time frame |
|---|---|
| Leicester cough questionnaire,LCQ;Pittsburgh sleep quality index, PSQI;Hull airway reflux questionnaire,HARQ;gastroesophageal reflux disease questionnaire, GerdQ;Generalized Anxiety Disorder-7, GAD-7;Patient Health Questionnaire-9, PHQ-9;Capsaicin cough sensitivity;Cough symptom score; | — |
Countries
China
Contacts
Public ContactLi Yu
Shanghai Tongji Hospital
Outcome results
None listed