Postoperative complications: postoperative acute kidney injury,myocardial injury after noncardiac surgery
Conditions
Interventions
Absolute threshold group:The intraoperative MAP was maintained above 70mmHg
Relative threshold group:Intraoperative SBP was maintained above 80% of baseline
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adult patients were scheduled for an elective intermediate-to high-risk abdominal or orthopedic surgical procedure under general anesthesia; 2. Aged > 60 years; 3. ASA classification I-III; 4. Patients were scheduled for surgery with an expected duration of 2 hours or longer; 5. Agree to participate in the study, accept follow-up, and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients were excluded if they had severe uncontrolled hypertension(SBP>= 180mmHg or diastolic blood pressure >= 110mmHg); 2. Preoperative MAP 3; 5. Patients had acute or decompensated heart failure or acute coronary syndrome; 6. Severe arrhythmia and severe valvular disease; 7. Patients had preoperative sepsis or were already receiving norepinephrine infusion; 8. Patients had chronic kidney disease(glomerular filtration rate < 30mL/min/1.73m2 or requiring renal replacement therapy for end-stage renal disease); 9. Restricted infusion was required during the operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of acute kidney injury by day 7 after surgery;Incidence of myocardial injury by day 7 after surgery;All-cause mortality at 30 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of f systemic inflammatory response syndrome by day 7 after surgery;Adverse events of each system;Unplanned admission rate to ICU;Length of stay; | — |
Countries
China
Contacts
Public ContactLiu Su
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed