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Effects of dexmedetomidine combined with dezocine assisted general anesthesia on perioperative inflammatory factors and cognitive function during thoracoscopic lung cancer surgery

Effects of dexmedetomidine combined with dezocine assisted general anesthesia on perioperative inflammatory factors and cognitive function during thoracoscopic lung cancer surgery

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200056217
Enrollment
Unknown
Registered
2022-02-01
Start date
2022-03-01
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

Experimental group:Dexmedetomidine combined with dezocine
Control group:General anesthesia

Sponsors

Fudan University Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Endoscopic lung tumor patients who signed informed consent; 2. Aged >= 50 years; 3. The ASA rating of the American Society of Anesthesiologists is Class I to II; 4. New York College of Cardiology (NYHA) Heart function Classification I to II; 5. Child-Pugh grade A and B.

Exclusion criteria

Exclusion criteria: 1. BMI40kg/m2 2. Patients with preoperative impairment of consciousness and cognitive function; 3. Coronary heart disease, serious arrhythmia, cardiopulmonary dysfunction, cerebrovascular accident; 4. Anemia patients; 5. High blood sugar; 6. Patients with liver and kidney dysfunction; 7. Patients with asthma, COPD, or pulmonary function examination indicating moderate or above ventilatory dysfunction; 8. Speech, and audiovisual dysfunction.

Design outcomes

Primary

MeasureTime frame
Inflammatory factor;Cognitive function assessment;

Secondary

MeasureTime frame
Arterial blood gas analysis during and after operation;Length of stay;Postoperation pain;Nausea and vomiting;Time of operation;Duration of mechanical ventilation;Length of stay in PACU;Procedure-related adverse events;

Countries

China

Contacts

Public ContactJun Zhang

Fudan University Cancer Hospital

sherrychen964@hotmail.com+86 13817153025

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026