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The safety and efficacy of intravenous administration of tranexamic acid for postoperative bleeding in spinal surgery

Safety and effectiveness of perioperative sequential intravenous tranexamic acid in the treatment of posterior spinal hemorrhage

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200056210
Enrollment
Unknown
Registered
2022-02-01
Start date
2022-02-01
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal degenerative disease

Interventions

Group A:Intravenous infusion of TXA 1g (200 mL TXA sodium chloride injection) 15 minutes before skin incision combined with intravenous infusion of TXA 1g every day 1 - 3 days after operation (24 hour
Group B:Intravenous infusion of TXA 1g 15 min before skin incision combined with intravenous infusion of 200 mL normal saline daily 1 - 3 days after operation (24 hours interval with the first infusio

Sponsors

The First Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 18 and 80 years; 2. Patients with lumbar vertebral disc herniation, lumbar spinal stenosis or lumbar spondylolisthesis; 3. The posterior lumbar interbody fusion (PLIF) technique was applied in patients; 4. Patients who provided written informed consent; 5. No abnormality was found in venous ultrasonography of both lower limbs.

Exclusion criteria

Exclusion criteria: 1. Preoperative anemia (Hb: female III; 8. Patients with history of any psychiatric illness; 9. Patients who had undergone lumbar surgery in the past; 10. Patients combined with lumbar tumor, tuberculosis, infection or lumbar vertebral fracture caused by trauma.

Design outcomes

Primary

MeasureTime frame
Total blood loss;Dominant blood loss;Hidden blood loss;Bood routine (Hct, Hb, RBC, PLT);Coagulation and fibrinolysis indexes (PT, INR, APTT, TT, FIB, FDP, D-D);Coagulation factors (II, V, VII, VIII, IX, X, XI, XII);Thrombelastogram (TEG);Length of stay (total length of stay, preoperative length of stay, postoperative length of stay);Drainage tube removal time, postoperative bed rest time to ambulation time;Liver and kidney function (ALb, ALT, AST, BUN, Cr);Postoperative complication (exudation, hematoma, infection);Incidence of venous thromboembolism (DVT, PE);Hospitalization expense;Duration of operation (min);Postoperative wound drainage volume;Red blood cell specific volume (HCT) of postoperative wound drainage fluid;Intraoperative blood loss;Height;Weight;—

Countries

China

Contacts

Public ContactZhenming Hu

The First Affiliated Hospital of Chongqing Medical University

spinecenter@163.com+86 13628326226

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026