Lung cancer
Conditions
Interventions
Experimental group:Medical thoracoscopy cryotherapy for malignant pleural effusion
Cisplatin/erythromycin control group:Sequential intrapleural infusion of cisplatin/erythromycin
Blank control group:Only the intrapleural tube was used to drain pleural effusion, and the local pleural cavity was not treated.
Sponsors
The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years; 2. Non-small cell lung cancer with pleural metastasis confirmed by histopathology or cytology; 3. ECOG score 0-1 points; 4. Cardiopulmonary function can tolerate painless medical thoracoscopy; 5. Patients who underwent medical thoracoscopy for the initial diagnosis of pleural effusion, underwent medical thoracoscopy cryotherapy at the same time as biopsy, and were confirmed to be non-small cell lung cancer by pathological results were also included in the study; 6. All subjects or their guardians must sign an informed consent form before entering the trial.
Exclusion criteria
Exclusion criteria: 1. Expected survival time 1.5 times the upper limit of normal); 4. Received chemotherapy or anti-angiogenic drug treatment (such as bevacizumab, endor, anlotinib, etc.; 5. History of radiotherapy; 6. History of local treatment in the thoracic cavity; 7. Multiple serous cavity effusion, or bilateral pleural effusion; 8. Patients who are allergic to erythromycin; 9. Those who cannot recruit the lungs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pleural progression free survival, P-PFS; | — |
Countries
China
Contacts
Public ContactDegan LU
The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
Outcome results
None listed