local advanced esophageal squamous cell carcinoma
Conditions
Interventions
Observation group:None
Sponsors
Department of Thoracic Surgery, Army Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Male or female, 18-80 years; 2. Squamous cell carcinoma of esophagus, clinical stage II-III; 3. ECOG score: 0-1; 4. No previous history of chemoradiotherapy or immunotherapy; 5. Survival time > 6 months; 6. No serious diseases of other systems, good organ function, able to tolerate the effects of chemotherapy on bone marrow function and other organs; 7. Able to tolerate surgery, with good cardiopulmonary and other organ function; 8. No definite requirement for fertility; 9. Subjects can read and fully understand the relevant content of the informed consent, and sign the informed consent at the same time.
Exclusion criteria
Exclusion criteria: 1. Patients with any active autoimmune disease or history of autoimmunity; 2. Patients who have used other drugs in clinical trials within 3 months before the first dose; 3. Patients treated with glucocorticoids one week before neoadjuvant therapy; 4. Patients who are pregnant or breastfeeding; 5. Patients with contraindications to related drugs; 6. Patients with abnormal liver function, AST, ALT greater than 1.5-2 times or above the normal value, and reatinine greater than the upper limit of normal value; 7. Patients with serious addictions, such as drugs, alcohol and heavy smoking; 8. Patients who have undergone digestive or respiratory surgery within 6 months; 9. Patients with severe mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| disease specific survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| progress free survival;minimal residual disease;pathologic complete response;circulating tumor DNA; | — |
Countries
China
Contacts
Public ContactWei Guo
Department of Thoracic Surgery, Army Medical Center
Outcome results
None listed