Intestinal dysfunction
Conditions
Interventions
Dexmedetomidine group:Dexmedetomidine and saline
Ulinastatin group:Ulinastatin and saline
Ulinastatin combined with dexmedetomidine group:Ulinastatin and dexmedetomidine
Control group:Saline
Sponsors
The Affiliated Hospital of Inner Mongolia Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. For those patients who are ready for elective laparoscopic colorectal-carcinoma surgery under general anesthesia combined with epidural anesthesia; 2. The estimated operation time is less than 4 hours; 3. Aged >= 40 years, American Society of anesthesiologists (ASA) grade I or II, and body mass index (BMI) of 18.5-24 kg/m^2; 4. Patients without serious cardiopulmonary, liver and kidney diseases, obvious mental disorders and long-term use of hormones and other special drugs; 5. Patients without concomitant digestive disorders other than colorectal cancer; 6. Patients without the history of gastrointestinal surgery, radiotherapy or chemotherapy; 7. All patients and their families were informed and willing to cooperate with the experiment.
Exclusion criteria
Exclusion criteria: 1. Patients with previous abdominal surgery; 2. Patients with any other diseases or pathological conditions that may interfere with the experimental results; 3. Identify the patients who are allergic to the study drug; 4. Patients with coagulation dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diamine oxidase;D-lactate;Time of first postoperative exhaust;Time of first postoperative defecation; | — |
Countries
China
Contacts
Public ContactHaixia Shi
The Affiliated Hospital of Inner Mongolia Medical University
Outcome results
None listed