pulmonary nodule
Conditions
Interventions
Dexmetomidine group:Dexmedetomidine 0.25 ug/kg/h intravenous pumping for 9 hours, 9: 00 p.m. the day after surgery to 6: 00 a.m. the next day
Saline group:0.9% Sodium Chloride Injection 3 ml/h intravenous pumping for 9 hours, 9: 00 p.m. the day after surgery to 6: 00 a.m. the next day
Sponsors
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.The patients agreed to participate in this research and signed the informed consents; 2.ASA Physical condition I-III; 3.Age from 18 to 65 years old (including 18 and 65); 4.Patients scheduled for single-site thoracoscopic resection of pulmonary lesions (wedge, segmental, lobectomy) under general anesthesia.
Exclusion criteria
Exclusion criteria: 1.The subjects and their families refuse to complete the clinical study; 2.Known to be allergic to research drug; 3.Pathological sinus syndrome, clinically significant sinus bradycardia, or secondary or higher heart block without pacemaker; 4.Severe liver dysfunction (Child-Pugh GRADE C) or severe renal failure (requiring dialysis); 5.Preoperative history of endocrine diseases, chronic lung diseases, immune diseases and respiratory tract infections, and abnormal coagulation; 6.Serious cardiac duct adverse events occurred during operation; 7.Other serious adverse events occurred after surgery, such as septic shock and acute renal failure; 8.Patients with a history of long-term use of analgesic sedation, psychotropic drugs, drug addiction and allergy to narcotic drugs; 9.A past history of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis; 10.If a physician or investigator violates the principles of study design during a clinical study, the ETHICS committee will terminate or suspend the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index, PSQI;Six-minute walk test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory biomarkers;Dosage of analgesic drugs;EuroQol five dimensions questionnaire;Numerical rating scale, NRS; | — |
Countries
China
Contacts
Public ContactBingbing Li
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Outcome results
None listed