allergic disease
Conditions
Interventions
Rapid immunotherapy group:Rapid immunotherapy
Sponsors
the third affiliated hospital of SUN Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Criteria for inclusion of research objects: 1. Age: over 5 years old, under 18 years old; 2. Children in line with the diagnostic and Treatment Guidelines for Allergic rhinitis in China 6, Diagnostic and Treatment Guidelines for Allergic Asthma in China 10 diagnosed allergic rhinitis, bronchial asthma, allergic rhinitis combined with asthma diagnostic criteria; 3. Positive diagnosis of dust mite allergen: dust mite skin prick test positive or allergen test shows dust mite allergy; 4. No severe asthma attack or other serious allergic diseases occurred recently; 5. Parents or guardians agree to AIT treatment and sign written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Severe or uncontrolled asthma [1 second forced expiratory volume (FEV1) < 70% predicted value]; 2. The symptoms cannot be controlled or the lung function continues to decrease after the application of grade 4 or 5 asthma control treatment plan; 3. Patients with two consecutive severe allergic reactions of unknown reason during the period of immunotherapy; 4. Are taking ß blockers, angiotensin converting enzyme inhibitors (ACEI) or monoamine oxidase inhibitors; 5. Suffering from serious cardiovascular and cerebrovascular diseases, immune diseases (including autoimmune diseases and immune deficiency diseases), malignant diseases, chronic infectious diseases; 6. Patients with severe mental illness, poor compliance or inability to understand the risks and limitations of treatment; 7. Those who have participated in clinical trials of AIT treatment in the past; 8. Other conditions that the researcher considers inappropriate for participating in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient symptom score;Patient levels of inflammatory cytokines; | — |
Countries
China
Contacts
Public ContactCheng Zhuanggui; Zhang Pingping
Outcome results
None listed