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The dose-response relationship of dexmedetomidine as an adjuvant to ropivacaine in ultrasound-guided supraclavicular brachial plexus block: a 5-arm parallel-group randomized trial

The dose-response relationship of dexmedetomidine as an adjuvant to ropivacaine in ultrasound-guided supraclavicular brachial plexus block: a 5-arm parallel-group randomized trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200056066
Enrollment
Unknown
Registered
2022-01-31
Start date
2022-02-15
Completion date
Unknown
Last updated
2024-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

upper extremity surgery

Interventions

Group 1 :Ultrasound-guided supraclavicular brachial plexus block with 30 mL 0.33% ropivacaine
Group 2:Ultrasound-guided supraclavicular brachial plexus block with 30 mL 0.33% ropivacaine plus 25 µg dexmedetomidine
Group 3:Ultrasound-guided supraclavicular brachial plexus block with 30 mL 0.33% ropivacaine plus 50 µg dexmedetomidine
Group 4:Ultrasound-guided supraclavicular brachial plexus block with 30 mL 0.33% ropivacaine plus 75 µg dexmedetomidine
Group 5:Ultrasound-guided supraclavicular brachial plexus block with 30 mL 0.33% ropivacaine plus 100 µg dexmedetomidine

Sponsors

East China Normal University Wuhu Affiliated Hospital (The Second People's Hospital of Wuhu)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Aged 18-80 years; 2.ASA grade I-III; 3.Elective upper limb surgery (except shoulder surgery); 4.BMI 18-25 kg/m^2; 5.Informed consent has been signed by the patient and his family.

Exclusion criteria

Exclusion criteria: 1.Patient's refusal or inability to cooperate and communicate; 2.Infection or tumor at puncture site; 3.Coagulation dysfunction; 4.Neurological dysfunction of the upper limb; 5.Respiratory insufficiency or high paraplegia; 6.Severe heart block or cardiac insufficiency; 7.Diabetes; 8.Pregnant women; 9.Any other situations in which researchers believe that patients should not participate in the this study.

Design outcomes

Primary

MeasureTime frame
The duration of analgesia;

Secondary

MeasureTime frame
Analgesic dosage for remedial analgesia within 24 hours and 24 to 48 hours after surgery;The duration of sensory and motor of block;Postoperative activity time and postoperative hospital stay;

Countries

China

Contacts

Public ContactDingdong Yang

East China Normal University Wuhu Affiliated Hospital (The Second People's Hospital of Wuhu)

yang.dd1220@aliyun.com+86 18055316715

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026