Sepsis
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 and = 2 points from baseline for patients with confirmed or suspected infection; 3. Confirmed or suspected bacterial infection (lung, abdominal cavity, urinary system or blood-borne infection); 4. Infection-related organ failure occurs within 48 hours; organ failure was defined as a sequential organ failure score (SOFA) >= 3 for at least one organ or system in the circulatory, respiratory, kidney, liver, coagulation, and central nervous system (i.e. newly emerging SOFA score >= 3 at any point in the screening period); 5. Informed consent signed by patient or guardian.
Exclusion criteria
Exclusion criteria: 1. Patients had end-stage diseases such as end-stage malignant tumor, end-stage lung disease, or had cardiac arrest, acute pulmonary embolism, blood transfusion reaction, and acute coronary syndrome within 4 weeks prior to enrollment; 2. Confirmed or highly suspected active viral hepatitis, or clinically confirmed active tuberculosis; 3. Uncontrolled bleeding within the previous 24 hours (i.e. clinically determined need for blood transfusion); 4. Extensive burns or chemical burns (i.e., third-degree burns > 30% BSA); 5. Allergic to the active ingredients or excipients of experimental drugs; 6. Participated in clinical intervention trials within the past 3 months; 7. Subjects are researchers or their immediate relatives, or patients who may have improper informed consent; 8. Patients considered unsuitable for the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hsa - miR - 138-5 p levels;SIRT1 level;Diamine Oxidase (DAO) level;intestinal fatty acid binding protein (i-FABP) level;D-lactic acid levels; | — |
Countries
China
Contacts
Public ContactChunbo Yang
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed