Clinical effectiveness of retrograde insular oral mucosal flap transposition of the facial artery in the treatment of severe dry eye

Insular infraorbital neurovascular pedicle labial salivary gland transplantation as a novel surgical procedure for the treatment of severe dry eye disease

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200056015

Enrollment

Unknown

Registered

2022-01-30

Start date

2020-02-01

Completion date

Unknown

Last updated

2024-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry eye disease

Interventions

Group 1 :Insular infraorbital neurovascular pedicle labial salivary gland transplantation

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Patients above 18 years of age; 2.Meet the diagnostic criteria for severe dry eye set by DEWS II; 3.Patients with Stevens-Johnson syndrome and chemical burn; 4.Cases unresponsive to alternative treatments such as artificial tears, anti-inflammatory drugs and immunosuppressive agents; 5.Salivary gland radionuclide scintigraphy was normal.

Exclusion criteria

Exclusion criteria: 1.The recovery period after eye surgery is less than 3 months; 2.Within the first 3 months of eye trauma; 3.Within the first 3 months of eye or eyelid herpes; 4.Active eye infection; 5.Within the first 3 months of active eye inflammation or a history of chronic, recurrent eye inflammation; 6.Sjogren's syndrome.

Design outcomes

Primary

Measure	Time frame
Best corrected visual acuity;Ocular surface disease index;Tear break up time;Schirmer test;Corneal fluorescein staining;	—

Countries

China

Contacts

Public ContactJie Ying

Beijing Tongren Hospital, Capital Medical University

jie_yingcn@aliyun.com+86 13693572296

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026