critical illness
Conditions
Interventions
Conventional nutritional support + probiotic group:Saccharomyces boulardii
Conventional nutritional support group:Conventional enteral nutritional
Sponsors
Department of Gastroenterology, Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients newly admitted to the ICU within 2 days; 2.Expected ICU stay of at least 2 days; 3.Have available enteral nutrition access; 4.Age >= 18 years; 5.Informed consent obtained.
Exclusion criteria
Exclusion criteria: 1.Nursing, pregnant patients; 2.Hypersensitivity to probiotics (fungal type); 3.Treatment regimen that includes oral or intravenous antifungal drugs; 4.Patients expected to die within 48 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recent infection;Fungemia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Results of catheter culture;Results of throat swab culture;Urine culture results;Changes of fecal flora abundance composition;Sequential Organ Failure Assessment Score;Acute Physiology and Chronic Health Evaluation II Score;Inflammation markers;Other biochemical test indices; | — |
Countries
China
Contacts
Public ContactJialin He
Department of Gastroenterology, the Second Affiliated Hospital of the Army Medical University
Outcome results
None listed