stress response
Conditions
Interventions
control group:Propofol combined with double-lumen bronchial catheter technique
experimental group:Remimazolam combined with visual double-lumen bronchial catheter technique
Sponsors
The General Hospital of Western Theater Command
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. ASA grade I~III; 2. Aged 18-60 years; 3. BMI <= 28kg/m2; 4. All subjects were intubated on the left side; 5. Double-lumen bronchial catheter technique was used for diagnosis; 6. Lung function is basically normal; 7. Not complicated with serious heart, brain and other important organ lesions; 8. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to benzodiazepines and any component of remazolam besylate for injection; 2. Schizophrenia or severe depression; 3. Long-term sedative and analgesic use history; 4. Drug or alcohol abuse history; 5. Intolerance Double-lumen bronchial catheter surgery; 6. Patients with difficult airway; 7. Fever, hoarseness or sore throat; 8. Any disease that affects the placement of the double-lumen tube with stenosis of the left main bronchus. 9. Unforeseen adverse events (such as drug allergy, anesthesia and surgical accident, etc.) occurred; 10. The patient was lost to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MAP before and after intubation;HR before and after intubation;Serum oxidative stress protein malondialdehyde concentration before and after intubation;Serum superoxide dismutase concentration before and after intubation;Glutathione peroxidase concentration before and after intubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intubation time;One-time intubation success rate;Number of catheter adjustments; | — |
Countries
China
Contacts
Public ContactHuang Qing-qing
the General Hospital Of Western Theater Command
Outcome results
None listed