Osteoarthritis of the knee
Conditions
Interventions
Group C:Periarticular local infiltrating drug (cocktail) consists of ropivacaine + epinephrine + dexamethasone + magnesium sulfate
Group D:Periarticular local infiltrating drug (cocktail) consists of ropivacaine + epinephrine + dexamethasone + sodium bicarbonate
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
20 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients requiring unilateral initial TKA surgery due to severe knee osteoarthritis; 2. Aged 18 to 80 years; 3. The American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) is I - III level.
Exclusion criteria
Exclusion criteria: 1. Allergic to anesthetic drugs and sulfa; 2. There were more than moderate intraoperative knee malformations (pronation and flexion malformations) and joint stiffness; 3. Alcoholic or long-term opioid users; 4. Language impairment and inability to perform pain numerical scales (NRS); 5. Surgical limb neuropathy; 6. Mental patients; 7. Patients with previous gastrointestinal ulcer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first postoperative remedial analgesia;Postoperative dosage of remedial morphine hydrochloride; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS pain score;Range of knee motion;Quadriceps strength;Incidence of postoperative complications;Daily walking distance;The duration of hospital stay;Inflammatory indicators; | — |
Countries
China
Contacts
Public ContactKang Pengde
West China Hospital, Sichuan University
Outcome results
None listed