type A aortic dissection
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with type A aortic dissection and undergoing aortic surgery; 2. Males and females aged 18 years or above; 3. Subjects with the ability to read and understand the consent form.
Exclusion criteria
Exclusion criteria: Previous neurological and psychiatric history, cerebral infarction within half a year, pregnancy, malignant tumor, extremely moribund patients with an expected life expectancy of fewer than 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stroke;Delirium;Preoperative quantitative EEG monitoring (F3-P3);Preoperative quantitative EEG monitoring (F4-P4);Quantitative EEG monitoring after anesthesia induction (F3-P3);Quantitative EEG monitoring after anesthesia induction (F4-P4);Quantitative EEG monitoring after cardiopulmonary bypass (F3-P3);Quantitative EEG monitoring after cardiopulmonary bypass (F4-P4);Quantitative EEG monitoring after deep hypothermic circulatory arrest (F3-P3);Quantitative EEG monitoring after deep hypothermic circulatory arrest (F4-P4);Quantitative EEG monitoring after rewarming (F3-P3);Quantitative EEG monitoring after rewarming (F4-P4);Quantitative EEG monitoring (F3-P3) within 1h after entering ICU;Quantitative EEG monitoring (F4-P4) within 1h after entering ICU;Quantitative EEG monitoring (F3-P3) 1st day of postoperation;Quantitative EEG monitoring (F4-P4) 1st day of postoperation;Quantitative EEG monitoring (F3-P3) 2nd day of postoperation;Quantitative EEG monitoring (F4-P4) 2nd day of postoperation;Quantitative EEG monitoring (F3-P3) 3rd day of postoperation;Brain function assessment;Brain function assessment;Brain function assessment;Brain function assessment;Quality of life (SF-36);Quality of life (SF-36);Quality of life (SF-36);Quality of life (SF-36);Time of postoperative revival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory related complications;All cause mortality;NSE;S100ß;CRP;TNFa;IL-6;IL-1a;IL-2;C3;C4;BNP;Measure the diameter of optic nerve sheath diameter;Measure pupil diameter; | — |
Countries
China
Contacts
Nanjing Drum Tower Hospital, Chinese Academy of Medical Science & Peking Union Medical College