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Neoadjuvant Immunotherapy combined with Chemotherapy for muscle invasive bladder cancer (NAIC): A multi-center, retrospective real-world study

The efficacy of PD-1 monoclonal antibody combined with chemotherapy in the treatment of patients with muscle invasive bladder cancer: A multi-center, retrospective real-world study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200055957
Enrollment
Unknown
Registered
2022-01-29
Start date
2022-01-29
Completion date
Unknown
Last updated
2024-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bladder cancer

Interventions

Case series:none

Sponsors

Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients with cT2-T4aNxM0 bladder urothelial carcinoma diagnosed by histopathology and imaging evaluation (patients with mixed histological tumors are required to be the dominant histological type of urothelial carcinoma); 2. The case information is complete.

Exclusion criteria

Exclusion criteria: 1. In addition to primary urothelial carcinoma, patients who also have other malignancies or have other malignancies in the past 5 years; 2. Before receiving tislelizumab and neoadjuvant chemotherapy, those who have received systemic chemotherapy, targeted or other immune checkpoint inhibitor drugs for the treatment of urothelial cancer; 3. Patients with less than 3 courses of medication prescribed in the study protocol; 4. The survival period is less than 6 months .

Design outcomes

Primary

MeasureTime frame
clinical complete response;pathological complete response;

Secondary

MeasureTime frame
Recurrence free survival;overall survival;Side effects;complications;bladder preseration rate;

Countries

China

Contacts

Public ContactWang Shaogang

Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology

sgwangtjm@163.com+86 27 83663460

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026