Celiac disease
Conditions
Interventions
The control group:Propofol as induction agent
0.1mg/kg/min remazolam benzenesulfonic group:0.1mg/kg/min remazolam benzenesulfonic as induction agent
0.2mg/kg/min remazolam benzenesulfonic group:0.2mg/kg/min remazolam benzenesulfonic as induction agent
Sponsors
The Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 65 years, regardless of gender; 2. Patients undergoing elective abdominal surgery under general anesthesia; 3. ASA score = 3 days.
Exclusion criteria
Exclusion criteria: 1. Time of emergency surgery or elective surgery = 160mmHg and/or diastolic blood pressure >= 100 mmHg); 4. Abnormal laboratory tests (anemia: Hb = 2.5xULN, TBIL >= 1.5xULN; Abnormal renal function, blood creatinine greater than the normal upper limit); 5. Acute angle-closure glaucoma, myasthenia gravis, acute alcoholism; 6. Patients with shock (systolic blood pressure <= 90mmHg) or coma; 7. Patients with allergy or drug resistance to benzodiazepines; 8. Pregnant or breast-feeding women; 9. Need to use cardiopulmonary bypass, hepatectomy or liver transplantation; 10. Participated in clinical trials of other drugs as a subject within the last 3 months; 11. The patient was deemed unsuitable to participate in the study by the researcher or refused by the patient himself.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation score (MOAA/SS score);Depth of anesthesia (BIS value);Analgesic intensity (Pain stress index);mean arterial pressure, MAP;Myocardial systolic index;Stroke volume index;systemic vascular resistance index;Sedation time;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactBai Yiping
The Affiliated Hospital of Southwest Medical University
Outcome results
None listed