preterm infants
Conditions
Interventions
control group:Conventional treatment
experimental group 1:Conventional treatment + mNGf@18 µg for consecutive 14d
experimental group 2:Conventional treatment + mNGf@18 µg for consecutive 28d
Sponsors
Henan Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Gestational age of 28-32 weeks, birth weight <1500g, male and female; 2. Agreed to undergo evaluation of brainstem auditory evoked potential (BAEP), head magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI); 3. The family members read the instructions and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Premature infants received other neurological medications during hospitalization; 2. Premature infants were found to have craniocerebral injury (intracranial hemorrhage, periventricular leukomalacia, ischemic hypoxic encephalopathy) by ultrasound examination once a week during hospitalization; 3. Premature infants were found to have severe liver and kidney diseases, blood disorders, autoimmune diseases and chronic and severe infections; 4. Allergic to mNGf.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| head MRI and DTI examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neonatal behavioral neurologic assessment;brainstem auditory evoked potential; | — |
Countries
China
Contacts
Public ContactZhang Jiajie
Henan Provincial People's Hospital
Outcome results
None listed