Postoperative cognitive dysfunction
Conditions
Interventions
Esketamine group (Group E):During induction, 0.5mg/kg intravenous injection of esticketamine was added
Operation control group (S group):Esketamine was not added during induction
Non-operative control group (NS group):Patients hospitalized at the same time without surgery were used as a blank control.
Sponsors
The 925th Hospital of PLA Joint Logistic Support Force
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the Esketamine group and the surgical control group were: 1. Patients aged 65 to 80 years; 2. Planned elective surgery under general anesthesia, surgery duration >= 2 hours; 3. ASA grade I-III. Inclusion criteria for the non-surgical control group were: 1. Aged 65 to 80 years; 2. Non-operative inpatients during the same period.
Exclusion criteria
Exclusion criteria: 1. Existing cognitive dysfunction before study; 2. Nerve, spirit system disease (Alzheimer's disease, cerebral thrombosis, cerebral infarction, etc.); 3. The use of sedatives or antidepressant drugs affected the nerve spirit system functions; 4. Cannot undertake neurocognitive function test; 5. Severe visual or auditory dysfunction; 6. Alcohol or drug dependence; 7. Main organs severe dysfunction; 8. Allergic to experimental drugs and contraindications of drug use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative cognitive function;Respiratory recovery time after anesthesia;Time to open eyes after anesthesia;Time of tracheal tube extraction after anesthesia;emergence agitation;Scores of VRS 30 minutes after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure during anesthesia;Heart rate during anesthesia;amount of bleeding;Infusion volume during anesthesia; | — |
Countries
China
Contacts
Public ContactWang Mei
The 925th Hospital of PLA Joint Logistic Support Force
Outcome results
None listed