premature ovarian insufficiency
Conditions
Interventions
Traditional Chinese medicine treatment group:None
The conventional treatment control group:None
Sponsors
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medicine Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnosis of early onset ovarian insufficiency (POI) based on the 2016 European Society of Human Reproduction and Embryology (ESHRE) POI guidelines: (1) Aged under 40 years old; (2) Two measurements (the second to fourth day of the menstrual cycle test, at least 4 weeks apart) FSH>25 iu/L; (3) Menstrual thinning or amenorrhea for at least 4 months. 2. Married women older than 18 years old have the requirement to have children; 3. Voluntarily participate in the study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Congenital abnormal development of reproductive organs, or hysterectomy, bilateral ovaries or bilateral salpingectomy; 2. Polycystic ovary syndrome, hyperprolactinemia, hyperandrogenemia, hypothyroidism, chronic adrenal hypothyroidism and other endocrine diseases affecting ovulation; 3. Complicated with serious cardiovascular, cerebrovascular, liver, kidney, hematopoietic system or malignant tumor, mental disease; 4. No pregnancy outcome; 5. POI subclinical patients; 6. The male body is healthy (no organic lesions in the reproductive system), and semen routine is basically normal; 7. Those who meet the inclusion criteria but cannot objectively cooperate with treatment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| AMH;Follicle stimulating hormone;Luteinizing hormone;Estradiol;Progesterone;Testosterone;Prolactin;MENQoL scale;FertiQoL scale;Adverse event;Health economics; | — |
Countries
China
Contacts
Public ContactLiu Jia
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medicine Sciences
Outcome results
None listed