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Study on the mechanism of TRPM8 in conscious pain and neurosensory abnormalities in dry eye

Study on the mechanism of TRPM8 in conscious pain and neurosensory abnormalities in dry eye

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200055880
Enrollment
Unknown
Registered
2022-01-22
Start date
2022-02-01
Completion date
Unknown
Last updated
2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry eye

Interventions

Experimental group:TRPM8 agonist (medical cold compress) combined with artificial tears
Control Group:artificial tears

Sponsors

Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Subjects with conscious pain and neurosensory abnormalities in dry eye, aged 18 years and over; 2. OSDI score >=13, tear breakup time 3 months; 4. Dry eye symptoms and signs separation; 5. FPS-R score >= 3.

Exclusion criteria

Exclusion criteria: 1. Patients with psychosis, cognitive dysfunction, cardiovascular and cerebrovascular accidents, malignant arrhythmia, and vital organ dysfunction; 2. Systemic connective tissue diseases and severe autoimmune diseases, such as rheumatoid arthritis, sarcoidosis, lupus erythematosus, thyroiditis, etc.; 3. Those who need to use eye drops for a long time with a history of eye surgery, a history of trauma or other diseases.

Design outcomes

Primary

MeasureTime frame
ocular surface disease index;FPS-R;corneal sensitivity;corneal nerve;TRPM8;—

Countries

China

Contacts

Public ContactZhang Zuhui

Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University

zhzhangeye@163.com+86 15268840754

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026