HAP/VAP
Conditions
Interventions
treatment group:Colistin sulfate aerosol inhalation
Sponsors
Changxing People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. HAP/VAP patients with respiratory tract infection/colonization by multidrug-resistant bacteria, the pathogen susceptibility test is sensitive to colistin; 2. Aged 18 years and over, male or female.
Exclusion criteria
Exclusion criteria: 1.Patients who refuse to join the group, or patients who cannot obtain blood and bronchoalveolar lavage fluid samples due to the unwillingness of the patient and the patient's family; 2.Those who have unacceptable adverse reactions or serious adverse reactions; 3.Pregnant women and lactating women; 4.Patients who have received colistin within 7 days prior to inclusion, regardless of dose or route of administration; 5.Known allergy to colistin or polymyxin family products; 6.Personal and family history of muscle weakness; 7.HBV, HCV and HIV seropositive; 8.Patients with a history of severe bronchial asthma in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Colistin concentration in miniBALF; | — |
Countries
China
Contacts
Public ContactLin Bin
Changxing People's Hospital
Outcome results
None listed