Effects of natural plant extracts (targeted inhibitors: PD0325901/AZ-628/ Neratinib/Selumetinib/ VX-11E) on chondrocyte and osteoclast microenvironment in osteoarthritis and its mechanism

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200055875

Enrollment

Unknown

Registered

2022-01-22

Start date

2021-01-01

Completion date

Unknown

Last updated

2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis, osteoporosis

Interventions

Normal Group:No intervention

Osteoarthritis Group:No intervention

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1 Over 18 years old; 2 knee osteoarthritis; 3 The main clinical manifestations were medial compartment lesions; 4 Genu varus deformity was found in the X-ray force line measurement of lower limbs.

Exclusion criteria

Exclusion criteria: 1 Medical records and treatment data are not complete; 2 There is a history of trauma, and there is injury or fracture of the main ligament of the knee joint; 3 Rheumatoid arthritis, suppurative arthritis and other joint diseases.

Design outcomes

Primary

Measure	Time frame
Protein of the matrix around cartilage and breakdown matrix protein;	—

Countries

China

Contacts

Public ContactZhenghua Hong

Taizhou Hospital of Zhejiang Province

0001hzh@163.com+86 13958550517

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026