The effect of dexmedetomidine on the plasma NfL and the Postoperative delirium

The effect of dexmedetomidine on the plasma NfL and the Postoperative delirium in older patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055869

Enrollment

Unknown

Registered

2022-01-22

Start date

2022-01-22

Completion date

Unknown

Last updated

2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The Postoperative Delirium

Interventions

Experimental group:Dexmedetomidine

Control Group:Normal saline

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients with thoracoscopic surgery and general anesthesia time > 60min; 2. Patients aged 60 years or older; 3. Patients with ASA I to III grade; 4. Patients stay in hospital for at least 72 hours after surgery.

Exclusion criteria

Exclusion criteria: 1. Patients with ASA IV grade or more; 2. Patients who had experienced alcohol withdrawal delirium, had a previous mental illness (schizophrenia, epilepsy or Parkinson's disease), were taking antidepressants, and had severe liver and kidney dysfunction (child-pugh C liver, serum creatinine >442umol/L); 3. Patients are allergic to any of the test drugs; 4. Patients with history of traumatic brain injury or neurosurgery; 5. Patients with severe bradycardia (heart rate below 40 beats/min), sick sinus syndrome, or atrioventricular block of grade 2 or higher, no pacemaker.

Design outcomes

Primary

Measure	Time frame
The plasma NfL;	—

Countries

China

Contacts

Public ContactZhou Qinghe

Jiaxing First Hospital

jxxmxy@163.com+86 13732573379

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026