Using Binocular Asynchronous Visual Images and Virtual Reality to Improve Amblyopic Eyes: A Randomized Controlled Trial

A Randomized Controlled Clinical Study to Evaluate Binocular Asynchronous Visual Images and Virtual Reality for Restoring Visual Function in Children With Anisometropic Amblyopia

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055848

Enrollment

Unknown

Registered

2022-01-20

Start date

2018-01-01

Completion date

Unknown

Last updated

2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amblyopia

Interventions

Experiment group 1:VR + Patching

Experiment group 2:VR only

control group:Patching

Eligibility

Sex/Gender

All

Age

4 Years to 17 Years

Inclusion criteria

Inclusion criteria: 1. Children aged 4 to 17 years old; 2. Significant anisometropia (>1.5 D difference between eyes in spherical equivalent; >1.0 D difference between the eyes in astigmatism, in any meridian.); 3. Optimal refraction prescribed by clinicians with extensive expertise in amblyopia. All had been wearing glasses for more than 3 months and had stable best-corrected visual acuity before entering the study; 4. VA in the AE before treatment between 20/32 Snellen acuity (0.2 logMAR) and 20/200 (1.0 logMAR). This definition for the threshold for amblyopia is slightly more stringent than that of the American Academy of Ophthalmology (VA in the AE before treatment 20/30 Snellen, 0.18 logMAR, or worse). The majority of children had initial VA in the AE worse than 0.3 logMAR; 5. The physical examination of Peking University First Hospital confirmed that the participants had normal psychophysiological development and did not suffer from any acute or chronic diseases or genetic visual system diseases.

Exclusion criteria

Exclusion criteria: 1. Clinical examination revealed any ocular disease in both eyes, including optic nerve or macular lesions, media opacities, or abnormalities of the central visual pathways; 2. The physical examination of Peking University First Hospital confirmed that the participants had abnormal psychophysiological development or had any acute or chronic diseases or genetic visual system diseases; 3. Voluntary subjects are excluded from participating in this study when they are found to have any of the above-mentioned examination results.

Design outcomes

Primary

Measure	Time frame
Distance Visual Acuity;	—

Countries

China

Contacts

Public ContactPu Mingliang

Peking University School of Basic Medical Sciences

mpu@bjmu.edu.cn+86 13501177695

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026