Alzheimer disease
Conditions
Interventions
Gold Standard:Senior expert panel review results.
Index test:Software assisted film reading, independent film reading by researchers
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
55 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 55 and over, no gender limitation; 2. There were 3D-T1 mri images of the brain; 3. Image layer thickness <= 1.2mm.
Exclusion criteria
Exclusion criteria: 1. There are obvious artifacts that affect the overall image quality in 3D-T1 magnetic resonance imaging, such as motion artifacts, metal artifacts, built-in artifacts, crimp artifacts, flow artifacts, pulsating artifacts, corduroy artifact, etc.; 2. Have a history of intracranial surgery; History of intracranial occupying disease; History of intracranial hemorrhage; History of trauma; History of duct disease and chronic softening foci; History of infectious diseases of the nervous system; History of congenital developmental abnormalities or malformations of the nervous system; Intracranial calcification foci; 3. Vascular dementia, frontotemporal lobe degeneration, Lewy body dementia, cortical basal ganglia degeneration, Parkinson's disease, dementia; 4. The researcher considered that the patients were not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The sensitivity and specificity of both software-assisted and investigator independent radiographs for the diagnosis of brain structural abnormalities in Alzheimer's disease were determined by the gold standard of radiographs reviewed by a senior expert group; | — |
Secondary
| Measure | Time frame |
|---|---|
| The accuracy of film reading between the experimental group and the control group; False positive rate and false negative rate; negative predictive Value and positive predictive value; Positive likelihood ratio, negative likelihood ratio;Sensitivity and specificity of independent film reading by software;Software performance evaluation; | — |
Countries
China
Contacts
Public ContactLu Jie
Xuanwu Hospital, Capital Medical University
Outcome results
None listed