oral squamous cell carcinoma
Conditions
Interventions
Experimental group:Preservation of the contralateral submandibular gland during bilateral neck dissection
control group:Resection of bilateral submandibular glands during bilateral neck dissection
Sponsors
Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.The age of the patient on the day of signing the informed consent is 18 years old or above; 2.The pathological diagnosis is oral squamous cell carcinoma; 3.Oral squamous cell carcinoma stage III-IVA; 4.No contralateral submandibular gland lesions; 5.No other oral mucosal lesions; 6.The vital signs are stable, and the routine examination shows that the operation can be tolerated; 7.Preoperative imaging report suggests ipsilateral lymph node metastasis of the primary tumor; 8.Those who need postoperative adjuvant radiotherapy; 9.The patient is in good mental state, can follow the doctor's orders, and have regular follow-up visits; 10.Understand and be willing to participate in this clinical trial and provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Pre-existing diseases that affect salivary secretion (such as autoimmune diseases); 2.Uncontrolled hyperglycemia (such as HbA1c >12.0%); 3.Those with severe uncontrolled disease or acute systemic infection, and those with other serious heart, lung, encephalopathy and other serious organ diseases; 4.Patients with psychiatric diseases; 5.Those who are considered inappropriate by the researchers; 6.The patient participated in this study at any time in the past; 7.Patients with cervical lymph node metastasis on the opposite side of the primary tumor were found by intraoperative pathological results
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| saliva secretion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival state;Recurrence or metastasis;VAS pain score;University of Washington Quality of Life Questionnaire; | — |
Countries
China
Contacts
Public ContactWang Youyuan
Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Outcome results
None listed