chronic pain after thoracic surgery, CPTS
Conditions
Interventions
control group (routine postoperative analgesia regime):PCIA(sufentanil 100ug, ondansetron 8mg, and dezocine 20mg and nomal saline)
experiment group (TPVB):TPVB(0.25% ropivacaine combined with 0.5 ug/kg DET+5 mg DEM)+ adjusted PCIA
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients going to have either side of pulmonary surgery under general anesthesia with double-lumen endobronchial tube; 2. Aged 18 years and over; 3. ASA classification: I-III; 4. Elective surgery; 5. With comprehensive preoperative tests including but not limited to, blood routine, pulmonary function test, hepatic and renal functions tests, and hemostatic and coagulation tests; 6. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients refuse to analgesia regime of TPVB or PCIA; 2.Unschedualed change of operation ways like open thoractomy or bilateral surgery; 3.Pneumonectomy or pulmonary sleeve resections; 4.Previous intrathoracic surgery history; 5.Subxiphoid approach pulmonary surgery; 6.Dysfunction in hemostatis or coagulation; 7.Infection in the range of puncture site of TPVB; 8.Allergic to the amide local anesthetics, dexmedetomidine or dexamethasone; 9.Preoperative heart rate lower than 50bpm; 10.Cognitive dysfunction, language barricade due to comprehension or expression, difficulty in scale comprehension; 11.Poor medical obedience, high tendency to medical contradiction; 12.Chronic pain history; 13.Drug abuse; 14.New York Heart Association, NYHA class of III-IV; 15.Canadian Cardiovascular Society, CCS class of III-IV; 16.Final stage of hepatic or renal dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of chronic pain 3 months after thoracic surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative NRS pain evaluation within 24hours;postoperative NRS pain evaluation within 48hours;The incidence of chronic pain 6 months after thoracic surgery;postoperative nausea and vomiting within 48hours;postoperative itch evaluation;motor block assessment;rescue analgesia consumption within postoperative 48hours;early postoperative ambulation time; | — |
Countries
China
Contacts
Public ContactGu Yang
Shanghai Pulmonary Hospital
Outcome results
None listed