Respiratory depression
Conditions
Interventions
N group:nalmefene + sufentanil
Sponsors
Department of Anesthesiology, Zhongda Hospital, Southeast University
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Adult male patients aged 18 to 65 years; 2. ASA grade I - II; 3. All surgical patients signed informed consent.
Exclusion criteria
Exclusion criteria: 1. History of opioid allergy or abuse; 2. Patients with abnormal liver and kidney function (alanine aminotransferase > 100u / L, aspartate aminotransferase > 100u / L, creatinine > 100umol / L); 3. Patients with hematological diseases or other hemorrhagic diseases; 4. Patients with a history of chronic obstructive pulmonary disease or severe asthma (need daily drug control or attack in the last month); 5. Patients with myasthenia gravis or other neuromuscular diseases; 6. Patients who cannot understand the significance of visual analog score (VAS); 7. Preoperative and intraoperative decision to bring the tube back to ICU patients after operation; 8. Contraindication of uvulopalatopharyngoplasty.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of respiratory depression;visual analogue scale (VAS) after extubation;Ramsay score after extubation; | — |
Countries
China
Contacts
Public ContactWang Jin
Zhongda Hospital Affiliated to Southeast University
Outcome results
None listed