colorectal cancer
Conditions
Interventions
Test group:Thymosin Alpha-1 subcutaneous injection
Control group:without Thymosin alpha-1
Sponsors
The Fourth Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 75 years old, regardless of gender; 2.Adenocarcinoma was confirmed by pathology before operation; 3.Imaging evaluation of tumor resectability; 4.Preoperative chest and abdominal CT examination was performed to determine the tumor stage and exclude distant metastasis; 5.ECoG score 70, can tolerate neoadjuvant chemotherapy and surgery after evaluation; 6.No radiotherapy and chemotherapy for tumor before randomization; 7.Laboratory index requirements: HB >= 90g/L (no blood transfusion within 14 days), ANC >= 1.5 x 10^9/L, PLT >= 80 x 10^9/L, TBIL 50ml / min. 8.Sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Multiple primary colorectal cancer; 2.The patient refused surgery and immunomodulator treatment; 3.The tumor cannot be removed; 4.Confirmed or suspected tumor metastasis; 5.ECoG score >= 2 or KPS score <= 70, physical condition can not tolerate chemotherapy or surgery; 6.The patient has signs of peritonitis or intestinal perforation and needs emergency surgical treatment; 7.Other reviewers believe that there are sufficient reasons for disqualification from the registration study: if there is potential nonconformity with the clinical protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD4 / CD8 ratio;CRP;PLR;NLR;1-year DFS;3-year DFS;2-year OS; | — |
Countries
China
Contacts
Public ContactNiu Wenbo
The Fourth Hospital of Hebei Medical University
Outcome results
None listed