Delirium
Conditions
Interventions
control group:Saline was given during the perioperative period.
Low dose group in prophase of weakness (L1 group):A loading dose of Dexametholidine (1mg/kg, within 10min) was pumped intravenously starting 10min before induction of anesthesia, and then a maintenanc
Low dose group in weakness (L2 group):A loading dose of Dexametholidine (1mg/kg, within 10min) was pumped intravenously starting 10min before induction of anesthesia, and then a maintenance dose of 0.
High dose group in prophase of weakness (H1 group) :A loading dose of Dexametholidine (1mg/kg, within 10min) was pumped intravenously starting 10min before induction of anesthesia, and then a maintena
High dose group in weakness (H2 group):A loading dose of Dexametholidine (1mg/kg, within 10min) was pumped intravenously starting 10min before induction of anesthesia, and then a maintenance dose of 0
Sponsors
The Third Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Elderly patients who underwent limb surgery under general anesthesia in our hospital; 2. Aged 60 years or over, regardless of sex; 3. ASA grade: I- III.
Exclusion criteria
Exclusion criteria: 1. Those who had dementia or a clear history of cognitive dysfunction, mental system disease, brain trauma, hearing, vision or language communication disorders could not complete this survey; 2. Patients with delirium were assessed as delirium before operation; 3. Emergency operation; 4. Patient or the guardian did not sign the informed consent form; 5. Major complications occurred during and after operation, such as cardiac arrest, pulmonary embolism and so on.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| POD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Arterial blood S100 ß;Interleukin 1 ß; | — |
Countries
China
Contacts
Public ContactLiu Yongzhe
Anesthesia Department of the Third Medical Center of PLA General Hospital
Outcome results
None listed