sepsis
Conditions
Interventions
Sepsis experimental group:Propofol group was given a sedative load of 2.5mg/kg propofol for 10min, followed by continuous pumping at 1mg/kg/h for 6h
Sepsis control group:sedated with Midazolam 0.05mg/kg, infusion time was 10min, and 0.9% normal saline was continuously pumped in the same way at the same volume and speed
Sponsors
PLA Army Specialty Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed as sepsis (1) Since the previous diagnostic indexes of "infection +SIRS presentation" are considered too sensitive, the current clinical diagnosis of adult sepsis requires definite infection or suspected infection plus the following indexes: 1) general condition: fever (>38.3?) or hypothermia (90 beats/min) or > 2 sd above normal for age; Increased respiration (>30 times/min); Consciousness change; Obvious edema or positive fluid balance > 20 ml/kg, lasting for more than 24h; Hyperglycemia (blood glucose >7.7mmol/L) and no history of diabetes; 2) Inflammatory indicators: leukopenia (>12 x 10^9/L or leukopenia (10%; Plasma C-reactive protein > normal value by 2 standard deviations; Plasma procalcitonin > normal by 2 standard deviations; 3) Hemodynamic indicators: hypotension (systolic blood pressure mmHg, mean arterial blood pressure 40 mmHg, or 2 standard deviations below normal for age); Mixed venous oxygen saturation (SvO2) > 70%; Cardiac index (CI) > 3.5 L/min/m2; 4) Organ dysfunction parameters: oxygenation index (PaO2/FiO2) Acute oliguria (urine volume 1.5 or activated partial thrombin time > 60s); Intestinal paralysis: the disappearance of intestinal sounds; Thrombocytopenia (70mmol/L); 5) Tissue perfusion parameters: hyperlactacemia (> 3 mmol/L); Prolonged capillary refill time or skin emergence; (2) Severe sepsis: sepsis complicated with organ dysfunction; (3) Septic shock: an otherwise unexplained state of acute circulatory failure characterized by hypotension, which is a specific type of severe sepsis. Include: 1) Systolic blood pressure 40mmHg for at least 1 hour, or dependent on infusion and medication to maintain blood pressure, mean arterial pressure 2 s; 3) Cold limbs or skin spots; 4) Hyperlactacemia; 5) Decreased urine output; 2. The patient gave informed consent, participated voluntarily, and signed the informed consent form; 3. Age: 18-80 years, 80 inclusive; 4. Register general medical conditions.
Exclusion criteria
Exclusion criteria: 1. Previous history of chronic heart disease, liver and kidney diseases; 2. Pregnant or menstruating women; 3. Preoperative radiotherapy and chemotherapy, and previous thoracic organ surgery (heart, lung, mediastinum); 4. Complicated with cardiovascular, liver, kidney and hematopoietic system and other serious primary diseases, as well as serious diseases affecting their quality of life; 5, Diabetes, hba1c > 7%; 6. Hyperthyroidism and abnormal thyroid function; 7. Abnormal blood lipid and uric acid metabolism; 8. Patients with mental diseases, cerebrovascular diseases or craniocerebral trauma; 9, Long-term use of sedative drugs or alcohol patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolomics test results; | — |
Secondary
| Measure | Time frame |
|---|---|
| arterial blood gas analysis;Oxidative stress index;markers of myocardial injury; | — |
Countries
China
Contacts
Public ContactLi Tao
PLA Army Specialty Medical Center
Outcome results
None listed