Resting state fMRI-guided precise localization transcranial magnetic stimulation for patients with chronic disorder of consciousness

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055745

Enrollment

Unknown

Registered

2022-01-17

Start date

2022-01-17

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic disorder of consciousness

Interventions

precising localization TMS group:precising localization TMS

TMS Group :conventional localization TMS

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients in coma for 28 days or more after traumatic brain injury. 2. All patients enrolled in the study received conventional medication, were right-handed, and had no focal intracranial lesions (as confirmed by MRI), a history of epilepsy, EPILEPtial-like activity in EEG, implanted pacemakers, aneurysm clips, vagus nerve stimulators, or brain/subdural electrodes.

Exclusion criteria

Exclusion criteria: 1. Patients whose consciousness increased or decreased significantly within 2 weeks prior to TMS treatment; 2. Patients with hearing impairment before onset; 3. Patients who cannot cooperate with TMS, MRI, or EEG; 4. Patients with a history of antipsychotic or antiepileptic use.

Design outcomes

Primary

Measure	Time frame
Coma Recovery Scale-Revised, CRS-R;	—

Countries

China

Contacts

Public ContactZang Yufeng

Deqing Hospital, Hangzhou Normal University

zangyf@hznu.edu.cn+86 18606517380

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026