Postherpetic neuralgia
Conditions
Interventions
The treatment group:5mg/Kg lidocaine was added into 500mL normal saline, and infusion speed was controlled by infusion pump. Infusion time was >= 1.5h. Before infusion, midazolam 1-1.5 mg and genasetr
The control group:5mg/Kg normal saline was added into 500ml normal saline, infusion speed was controlled by infusion pump, infusion time >= 1.5h. Before infusion, midazolam 1-1.5 mg and genasetron 3mg
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. Diagnosis of postherpetic neuralgia; 3. Agree to the experiment and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with serious atrioventricular block; 2. Patients with serious heart diseases leading to heart failure, or serious multiple organ failures; 3. Delirium, senile dementia and other self-awareness disorders, unable to communicate with patients; 4. Patients who are not cooperative and refuse to accept the treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional connectivity in the resting state fMRI;the area activated of brain in the task-based fMRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| the change of allodynia and Pain threshold;The change of the degree of pain and its influencing factors;the emotional change;the quality of life;dosage of analgesic drugs; | — |
Countries
China
Contacts
Public ContactXiao Hong
West China Hospital, Sichuan University
Outcome results
None listed