Major abdominal surgery
Conditions
Interventions
Group Propofol:Nil
Group Propofol-Esketamine :Nil
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60 to 80 years; 2. ASA I–III; 3. Patients undergoing elective general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Long term use of sedative drugs or antidepressant drugs and other mental illnesses; 2. Patients refuse to understand the agreement and sign the informed consent; 3. Myocardial infarction, heart failure in past 6 months; 4. Acute stage of cerebrovascular disease; 5. Severe arrhythmia; 6. Severe respiratory diseases; 7. Poorly controlled hypertension or patients who are at serious risk of increased intracranial pressure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure, BP;CO;Mean arterial pressure, MAP;Heart rate, HR;oxygen saturation, SPO2;Cardiac index, CI;stroke volume variation, SVV; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of adverse events, such as hypotension, hypertension, etc.;Postoperative complications, delirium, mental symptoms, etc.; | — |
Countries
China
Contacts
Public ContactHu Jihua
The First Affiliated Hospital of Soochow University
Outcome results
None listed