gallbladder cancer
Conditions
Interventions
experimental group:AG regimen chemotherapy
Sponsors
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Sign a written informed consent; 2. Aged 18-75 years, including 18 and 75 years; 3. ECOG score 0-2 points, Child-Pugh grade A; 4. Those diagnosed by histopathology or cytology are not suitable for radical surgery (R0), or undergo non-radical surgery (R1), or undergo palliative surgery, or patients with recurrent and metastatic gallbladder cancer; 5. The functional indicators of vital organs meet the following requirements: (1) Hematological indicators are basically normal: absolute neutrophil count >= 1.5 x 10^9/L; platelet >= 75 x 10^9/L; hemoglobin >= 90 g/L; (2) Renal function is basically normal: serum creatinine = 60 mL/min (3) The liver function is basically normal: serum total bilirubin = 3 months; 7. Non-lactating or pregnant women, contraception during treatment and 3 months after the end.
Exclusion criteria
Exclusion criteria: 1. Severe systemic infection, or other systemic serious uncontrollable diseases (such as heart failure, thyroid disease, mental disease, etc.); 2. Those who are known to be allergic or intolerant to chemotherapy drugs or their excipients; 3. Received anti-tumor treatment (chemotherapy, radiotherapy, immunotherapy) or had any malignant tumor at present or in the past 1 year, except cured cervical carcinoma in situ and non-melanoma skin cancer; 4. Pregnancy or breastfeeding, and childbearing age who refuse to take appropriate contraceptive measures during this trial; 5. Participated in other experimental studies within 30 days before the administration of the first dose of the study drug; 6. Other factors judged by the investigator may affect the subject's safety or test compliance. Such as serious illness (including mental illness) requiring concomitant treatment, serious laboratory test abnormalities, or other family or social factors; 7. Note: When screening, the researcher should ensure that the subjects meet all the inclusion criteria. If the subject's condition changes (including laboratory test results) after screening but before the first dose of study drug is administered and meets the exclusion criteria, the subject should be excluded from the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate; | — |
Countries
China
Contacts
Public ContactWei Gong
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed