Lung tumor
Conditions
Interventions
early block group:intercostal nerve block before operation
routine block group : intercostal nerve block under direct vision before operation
blank control group:no preoperative or postoperative intercostal nerve block
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
26 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Two port thoracoscopic lobectomy was performed; 2. Aged 18 ~ 70 years, regardless of gender; 3. ASA grade I - II; 4. Cardiac function grade I - II (NYHA grade); 5. Preoperative imaging diagnosis of bronchial lung cancer below the secondary bronchus requires a single lobectomy. Imaging showed that the maximum diameter of the tumor was 50%, FEV1% > 50% predicted value, FEV1 / FVC > 70%) and other important organ functions are basically normal, and can tolerate lobectomy; 7. If antibiotics have been used before the operation, the interval from stopping the use of antibiotics to the start of intravenous drip before the operation shall be at least 24 hours; 8. If painkillers have been used before the operation, the interval from stopping to the beginning of the operation shall be at least 24 hours.
Exclusion criteria
Exclusion criteria: 1. Combined medical history, operation history or symptoms that may lead to increased postoperative drainage, such as clear history of tuberculosis, history of operation on the same side of thorax, chest volume of chest fluid or moderate volume of pleural effusion. Complicated with pulmonary infection; Or combined with medical history or clinical manifestations that other researchers believe may cause postoperative air leakage, such as diffuse emphysema; 2. Imaging findings suggest that there are anatomical abnormalities such as ectopic vena cava, which may cause difficulty in vagus nerve block; Calcification or lymph node fusion of hilar and mediastinal lymph nodes; 3. Water and electrolyte disorders, bronchial asthma, diabetes, anemia (male hemoglobin lower than 120g/L, female hemoglobin lower than 110g/L), hypoalbuminemia (albumin below 35g/L) and other patients can be corrected after internal medicine correction. 4. Combined with other absolute surgical contraindications or suffering from other types of malignant tumors, menstrual period, pregnancy and other conditions that researchers believe are not suitable for inclusion; 5. Penicillin, cephalosporin, morphine, contrast agent or drug allergy involved in the protocol; 6. Prolonged hospitalization due to serious surgical complications (such as massive bleeding, respiratory failure, etc.); 7. Second operation; 8. Unilateral multiple lung masses; 9. Preoperative radiotherapy and chemotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain score;The amount of remedial analgesics within 48 hours after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative vital signs;Muscle relaxants, opioids, sedative dosage, operation time, anesthesia time, fluid inflow and outflow;Postoperative recovery;Postoperative hospitalization time, postoperative chest extubation time, postoperative exhaust, defecation and eating time, and patients' underground activity time;;Incidence of postoperative adverse events;Blood routine examination, blood gas results and PCT before and after operation;Pain at 1, 2 and 3 months after operation; | — |
Countries
China
Contacts
Public ContactLan Lan
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed