Ischemic Stroke
Conditions
Interventions
Group 1 :Drug treatment
Group 2:Endovascular treatment
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 40-75 years old; 2. DSA or CTA confirmed unilateral occlusion of the intracranial segment of the internal carotid artery or the middle cerebral artery, and the occlusion segment is within 2 cm; 3. The clinical symptoms and signs are consistent with the responsible vessel; 4. CTP/MRP showed hypoperfusion in the supply area of the responsible artery; 5. Occlusion in the non-acute stage, with onset time of more than 24 hours; 6. mRS score <= 1 before onset; 7. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with massive cerebral infarction and cerebral hemorrhage in the past; 2. Combined with intracranial aneurysm, intracranial arteriovenous malformation and other cerebrovascular malformations; 3. Internal carotid artery occlusion caused by Takayasu arteritis or dysplasia; 4. Patients who have been diagnosed with vascular dementia; 5. Allergy to aspirin or clopidogrel or corresponding contraindications; 6. Allergy to iodine agent or contrast agent, serum creatinine > 3 g/L or other contraindications for cerebral angiography; 7. mRS score > 1 before onset; 8. Other planned surgical operations or interventional treatments may require termination of the trial drug. Diagnosed or probable acute coronary syndrome; 9. Undergoing experimental drug or instrument test. Are undergoing experimental drug or device testing; 10. Women of childbearing age, pregnant or lactating women who have a negative pregnancy test but refuse to take effective contraceptive measures; 11. Participated in other clinical drug research in the past 30 days; 12. Patients with coronary heart disease or previous myocardial infarction before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recurrence of stroke; | — |
Countries
China
Contacts
Public ContactLi Jingwei
Department of Neurology, Drum Tower Hospital
Outcome results
None listed