acute respiratory distress syndrome
Conditions
Interventions
control group:Protective low tidal volume ventilation
experimental group:Protective low tide volume and right center monitoring guide parameter setting
Sponsors
The Second Affiliated Hospital, Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with moderate to severe ARDS who meet the diagnostic criteria of the Berlin definition; 2. Endotracheal intubation and mechanical ventilation time is less than 48 hours; 3. Aged >= 18 years.
Exclusion criteria
Exclusion criteria: 1. Severe obstructive pulmonary disease; 2. Bullae or pneumothorax, subcutaneous emphysema, mediastinal emphysema; 3. Pregnancy; 4. BMI >= 35 kg/m2; 5. Suspected pulmonary vascular hemorrhage; 6. Dying state or terminal disease; 7. Neuromuscular disease; 8. Hematological malignancies, bone marrow transplantation; 9. Severe cardiac dysfunction (New York Heart Association Class III or IV, acute coronary syndrome or sustained ventricular tachyarrhythmia), cardiogenic shock or major cardiac surgery; 10. Refractory shock (despite adequate fluid resuscitation, use of large doses of vasoactive drugs: norepinephrine equivalent dose > 1 ug/kg/min, MAP is still < 60 mmHg); 11. Failure to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intensive care unit mortality; | — |
Countries
China
Contacts
Public ContactLu Zhonghua
The Second Affiliated Hospital, Anhui Medical University
Outcome results
None listed