End-stage renal disease
Conditions
Interventions
Group 1:After calibration of the TOF-Watch SX, an i.v. bolus dose of rocuronium 0.6 mg/kg is given for tracheal intubation, with maintenance doses 0.15 mg/kg if T2 reappears to maintain moderate NMB.
Group 2:After calibration of the TOF-Watch SX, an i.v. bolus dose of rocuronium 0.6 mg/kg is given for tracheal intubation, with maintenance doses 0.15 mg/kg if T2 reappears to maintain moderate NMB.
Sponsors
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing emergency renal transplantation under general anesthesia (creatinine clearance CLCR <= 30 ml/min); 2. Average age between 18 and 65 years old; 3. ASA Grade II to III.
Exclusion criteria
Exclusion criteria: 1. Suffering from neuromuscular system diseases, liver dysfunction, severe respiratory diseases and personal or family history of malignant hyperthermia; 2. Pregnant or lactating women; 3. Difficult airway, sleep apnea syndrome and body mass index >= 28 kg/m2; 4. Allergic to anesthetic drugs, muscle relaxants and other drugs used during general anesthesia; 5. Patients who have recently taken the following drugs: aminoglycoside antibiotics, anticonvulsants, magnesium, toremifene, fusidic acid and flucloxacillin during the perioperative period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative graft function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean Time From Start of Administration of Sugammadex to Recovery of the T4/T1 Ratio to 0.9;Residual neuromuscular block; | — |
Countries
China
Contacts
Public ContactTang Yiyang
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed