Coronavirus Disease 2019 (COVID-19)
Conditions
Interventions
case series:Nil
Sponsors
First Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. Participants aged 18-59 years old; 2. Participants who had finished the third dose of inactivated vaccine against SARS-CoV-2 ((BBIBP-CorV) more than 6 months.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to any component of the vaccine, and those who have history of severe allergic reactions to the vaccine, such as acute allergic reactions, urticaria, skin eczema, dyspnea, angioedema or abdominal pain; 2. Those with fever or those who suffer from acute diseases or severe chronic diseases in the acute stage of onset; 3. Pregnant women, lactating women, or having a pregnancy plan within 3 months; 4. Patients with a history or family history of convulsions, epilepsy, encephalopathy or mental illness; Patients with uncontrolled epilepsy and other progressive neurological diseases; Patients with a history of Guillain-Barré syndrome; 5. Those who have been diagnosed with congenital or acquired immunodeficiency HIV infected lymphoma leukemia or other autoimmune diseases; 6. Those who have severe respiratory diseases, severe cardiovascular diseases, liver and kidney diseases and malignant tumors; 7. A history of COVID-19 infection; 8. Patients who take medicine affecting the immune function, such as immunosuppressant agents or immunopotentiators or glucocorticoids ( >= 10 mg prednisone or other equivalent glucocorticoids) within one month before enrollment; 9. Those who are considered unsuitable for vaccination by clinicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SARS-CoV-2 RBD antibodies;Immunocell phenotype;Adverse events;pseudotype virus antibody neutralisation assay; | — |
Countries
China
Contacts
Public ContactPeng Sui
First Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed